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et al., 2019) intraperitoneally into a rat model of SCI and found that the Xc-GSH-GPX4 axis was upregulated to inhibit Ferroptosis, thereby improving the functional recovery of SCI in rats

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In summary, our discovery of the isoxazole Acs inhibitors and the structural and biochemical characterization of their mechanism of inhibition provides novel insights that should be useful to the design of Acs inhibitors for both infectious disease indications as well as the treatment of human cancers and metabolic diseases